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Title: | Toe-brachial index is beyond a peripheral issue in patients with type 2 diabetes |
Authors: | Gisoo Darban Hosseini Amirkhiz |
Subject: | diabetes |
Issue Date: | 2021 |
Abstract: | Background Atherosclerosis is the leading cause of death in patients with diabetes. We aimed to evaluate the association between ankle-brachial index (ABI) and toe-brachial index (TBI) with carotid intima-media thickness (CIMT) in patients with type 2 diabetes (T2DM). Methods This cross sectional study included 296 patients with T2DM who met the American Diabetes Association criteria for the assessment of peripheral arterial atherosclerosis. The ABI � 0.9 and TBI � 0.7 were considered as abnormal values. Linear and logistic regression analyses were performed to evaluate the association between TBI/ABI and CIMT. Results Right CIMT was significantly greater in the low TBI group (p = 0.03) while, left CIMT did not show a significant difference. Each 0.1-unit decrease in TBI value was independently associated with 0.017 mm increase in the right CIMT (β ± SE; -0.017 ± 0.005, p = 0.002) and with odds of the presence of increased CIMT [odds ratio and 95% confidence interval: 1.21 (1.02, 1.44)] after adjustment with all traditional risk factors. There was not any significant association between ABI and increased CIMT. Conclusions Beyond a suitable tool for the diagnosis of peripheral artery disease in patients with T2DM, TBI can be applied for prediction of subclinical carotid atherosclerosis. |
URI: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253138 http://dl.iem.iums.ac.ir/handle/Hannan/823 |
Type: | Article |
Appears in Collections: | Diabetes |
Files in This Item:
File | Description | Size | Format | |
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Toe-brachial khamase 2021.pdf | 602.67 kB | Adobe PDF | View/Open |
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