Please use this identifier to cite or link to this item: http://dl.iem.iums.ac.ir/handle/Hannan/1040
Title: Diabetic Nephropathy;Methods and Protocols
Subject: Diabetic Nephropathies
Issue Date: 2020
Publisher: Humana Press
place: New York
Abstract: Diabetic nephropathy represents the leading cause of end-stage renal failure in the Western world. New treatments to either prevent this condition or delay its relentless progression are urgently needed. In this book, we have put together a toolkit of novel research approaches for investigators to study diabetic nephropathy. We hope that this will foster new research directions and inspire ideas to enhance our understanding of diabetic nephropathy and to develop treatments for this condition. Experimental models are critical for basic science studies in the field of diabetic nephropathy, and our book describes a wide range of current models from the fly to the fish, cells in culture, and in vivo mammalian approaches. Successful studies in the field of diabetic nephropathy also require powerful techniques to image the kidney. This is an area where technological advances are rapidly occurring. Our book reflects this, and we describe not only traditional histological techniques to visualize diabetic kidneys but also innovative new approaches in electron, confocal, and two-photon microscopy. The pathophysiology of the diabetic kidney is complex, and we describe a range of techniques that can unravel these processes by examining changes in the properties of cells that make up the kidney filtration barrier, assess endoplasmic reticulum stress, apoptosis, and cell–cell interactions. The last decade has also seen major advances in techniques which take a global approach to assessing microRNAs, genes, proteins, and metabolites in disease conditions, and these are described in relation to diabetic nephropathy. Finally, advances in the renal field in gene editing and regenerative medicine are described. Although these have not been used extensively in diabetic kidney disease to-date, they provide great promise for the future. We are grateful to all that have contributed to this book and whose aim is to help patients with diabetic kidney disease. We hope this book will support the reader in their research and help researchers to develop innovative experimental approaches in the field of diabetic nephropathy.
URI: http://dl.iem.iums.ac.ir/handle/Hannan/1040
ISBN: 9781493998401
1493998404
Type: Book
Appears in Collections:Nephrotic syndrome

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